Correction of urine cotinine concentrations for creatinine excretion: is it useful?

نویسندگان

  • Peter Jatlow
  • Sherry McKee
  • Stephanie S O'Malley
چکیده

and activation by cadmium. Clin Chim Acta 1982;123:221–31. 8. Lenney JF, Peppers SC, Kucera-Orallo CM, George RP. Characterization of human tissue carnosinase. Biochem J 1985;228:653–60. 9. Teufel M, Saudek V, Ledig J, Bernhardt A, Boularand S, Carreau A, et al. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. J Biol Chem 2003;278:6521–31. 10. Pegova A, Abe H, Boldyrev A. Hydrolysis of carnosine and related compounds by mammalian carnosinases. Comp Biochem Physiol B Biochem Mol Biol 2000;127:443–6. 11. Tabakman R, Lazarovici P, Kohen R. Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia. J Neurosci Res 2002;68:463–9. 12. Kang JH, Kim KS, Choi SY, Kwon HY, Won MH, Kang TC. Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu, Zn-superoxide dismutase modification. Biochim Biophys Acta 2002; 1570:89–96. 13. Boldyrev A, Song R, Lawrence D, Carpenter DO. Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species. Neuroscience 1999;94:571–7. 14. Boldyrev AA. Problems and perspectives in studying the biological role of carnosine. Biochemistry (Moscow) 2000;65:751–6. 15. Newman MF, Kirchner JL, Phillips-Bute B, Gaver V, Grocott H, Jones RH, et al. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med 2001;344:395–402. 16. Orfanos AP, Guthrie R, Jinks DC. A fluorometric micromethod for estimation of carnosinase in dried blood samples. Clin Chim Acta 1987;166:219–25. 17. Chen RF, Scott C, Trepman E. Fluorescence properties of o-phthaldialdehyde derivatives of amino acids. Biochim Biophys Acta 1979;576:440–5. 18. Yoshimura T, Kamataki T, Miura T. Difference between histidine and histamine in the mechanistic pathway of the fluorescence reaction with ortho-phthalaldehyde. Anal Biochem 1990;188:132–5.

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Replacing creatinine measurements with specific gravity values to adjust urine cotinine concentrations.

Creatinine and specific gravity (relative density) measurements both allow differences in urine concentration to be taken into account in determining urine cotinine concentrations. In this study we demonstrate that the variance of urine cotinine measurements is reduced comparably when either creatinine or specific gravity measurements are used for correction. This reduction in variability impro...

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عنوان ژورنال:
  • Clinical chemistry

دوره 49 11  شماره 

صفحات  -

تاریخ انتشار 2003